The symptoms that will help you better understand iMCD

The symptoms of idiopathic multicentric Castleman disease (iMCD) may vary from person to person, which makes getting an accurate diagnosis for this rare disease difficult. Knowing the symptoms of iMCD and reporting any that you experience to your doctor may help you get an accurate diagnosis.

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Swollen Lymph Nodes

Enlarged or swollen lymph nodes may be found throughout the body.

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Fatigue

Having low energy or feeling overtired.

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Anemia

A condition in which a person has a low red blood cell count and might feel tired.

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Enlarged Organs

The liver or spleen may be larger than normal.

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Night Sweats

Repeated episodes of excessive sweating during sleep.

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Fever

A key sign that the immune system has been activated.

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Unintended Weight Change

Significant change in weight can be a sign of an underlying medical condition.

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Flu-like Symptoms

Fever, night sweats, cough, fatigue, and weight loss.

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Rash

An area of the skin that may become red, scaly, and itchy.

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Fluid Accumulation

Swelling caused by excess fluid in body tissues.

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If you are a patient or a caregiver, be sure to report even common flu-like symptoms to your doctor.

The symptoms that led up to my iMCD diagnosis included visibly swollen lymph nodes, fatigue, brain fog, night sweats, headaches, feeling dizzy, and nausea.

– Jessica, iMCD patient

Jessica, iMCD patient testimonial Sylvant
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Insights on iMCD

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Have you been prescribed SYLVANT® (siltuximab) for the treatment of iMCD?*
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SYLVANT® (siltuximab) for injection

APPROVED USE

SYLVANT® (siltuximab) is a prescription medicine used to treat people with multicentric Castleman’s disease (MCD) who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection.

It is not known if SYLVANT is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take SYLVANT if you have had a severe allergic reaction to siltuximab or any of the ingredients in SYLVANT. See the Patient Information for SYLVANT for a complete list of ingredients.

SYLVANT® (siltuximab) for injection

APPROVED USE

SYLVANT® (siltuximab) is a prescription medicine used to treat people with multicentric Castleman’s disease (MCD) who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection.

It is not known if SYLVANT is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take SYLVANT if you have had a severe allergic reaction to siltuximab or any of the ingredients in SYLVANT. See the Patient Information for SYLVANT for a complete list of ingredients.

Tell your healthcare provider if you have an infection. You should not receive SYLVANT if you have a severe infection.

Tell your healthcare provider if you have had a recent vaccination or are scheduled to receive any vaccinations. You should not receive a live vaccine during your treatment with SYLVANT.

Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if SYLVANT will harm your unborn baby. You should not become pregnant while receiving treatment with SYLVANT. Females who are able to become pregnant should use effective birth control during treatment with SYLVANT and for 3 months after stopping treatment.

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if SYLVANT passes into your breast milk. You and your healthcare provider should decide if you will take SYLVANT or breastfeed. You should not do both.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of SYLVANT include rash, itching, upper respiratory tract infection, swelling, weight gain, and increased blood level of uric acid.

These are not all the possible side effects of SYLVANT. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For more information, please see the full Prescribing Information.

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