A portrayal of a doctor helping an older patient A portrayal of a doctor helping an older patient

Why Sylvant

Starting SYLVANT

Patient portrayal

What you need to know about receiving SYLVANT

Before icon
Before the infusion

For the first 12 months of SYLVANT therapy, your doctor will order blood tests before each infusion to make sure your body is ready for treatment. After that, you will need blood work every 3 dosing cycles.

Before each visit, it may be helpful to write down how you have been feeling and any thoughts or questions you may have.

Schedule icon
Scheduling the infusion

Where you go for your SYLVANT infusions is up to you and your doctor. You may decide to go to a specialized academic center, a local community hospital, or an infusion center. For some patients, home infusion may be an option.*

Select a location that is most convenient to you.

  • *Insurance coverage of home infusion treatments varies by patients’ provider and plan. SYLVANT treatment must be initiated in an office or clinic setting
 before transitioning to home infusion.
Getting infusion icon
Getting the infusion

The SYLVANT infusion: 1 hour every 3 weeks

While the actual infusion only takes 1 hour, you should expect to be at the infusion center longer for other things such as blood work, preparation of the infusion, and meetings with your doctors.

Jessica, living with iMCD since 2017

When I received my idiopathic multicentric Castleman disease (iMCD) diagnosis, I was relieved because I knew I was going to receive the proper treatment…and that made me hopeful 
for the future.

– Jessica, living with iMCD since 2017

Infusion day

When it comes to your SYLVANT infusion days, it’s important to be good to yourself. Give yourself plenty of time to get to the appointment and have enough time to talk with your doctor, infusion nurse, or healthcare practitioner.

Here are some tips that may help you plan for infusion day:

Loose-clothing icon

Wear loose-fitting clothing and layers in case you get too warm or too cold.

Take it easy icon

Get a good night’s sleep before the day of your SYLVANT infusion.

Good breakfast icon

Have a good breakfast—it’s important to keep your strength up.

Good night's sleep icon

Plan to take it easy for the rest of the day after an infusion.

You're not alone

We’re here to help make it easier for you to access and stay on treatment.

IL-6, interleukin-6; R.A.R.E., Recordati Access, Resources, and Engagement.

What is SYLVANT?

SYLVANT® (siltuximab) is a prescription medicine used to treat people with multicentric Castleman’s disease (MCD) who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection. It is not known if SYLVANT is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Who should not receive SYLVANT?

Do not receive SYLVANT if you have had a severe allergic reaction to siltuximab or any of the ingredients in SYLVANT. See the Patient Information leaflet for SYLVANT for a complete list of ingredients.

Before starting SYLVANT, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have an infection. You should not receive SYLVANT if you have a severe infection.
  • have had a recent vaccination or are scheduled to receive any vaccinations. You should not receive a live vaccine during your treatment with SYLVANT.
  • have or have had any stomach or bowel (intestine) problems, such as diverticulitis or ulcers. Tell your healthcare provider if you have pain in your stomach area.
  • are pregnant or plan to become pregnant. It is not known if SYLVANT will harm your unborn baby. You should not become pregnant while receiving treatment with SYLVANT. Females who are able to become pregnant should use effective birth control during treatment with SYLVANT and for 3 months after stopping treatment.
  • are breastfeeding or plan to breastfeed. It is not known if SYLVANT passes into your breast milk. You and your healthcare provider should decide if you will take SYLVANT or breastfeed. You should not do both.Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SYLVANT?

SYLVANT may cause serious side effects, including:

  • Infections. SYLVANT may lower your ability to fight infections. Tell your healthcare provider right away if you have any signs or symptoms of an infection during treatment with SYLVANT.
  • Infusion and allergic reactions. If you have an infusion or allergic reaction while receiving SYLVANT, your healthcare provider will stop your infusion and treat your reaction. If you have a severe infusion or allergic reaction, your healthcare provider may stop your treatment completely. Tell your healthcare provider or get medical help right away if you have any of these symptoms during or after your infusion of SYLVANT: back pain, chest pain or tightness, nausea and vomiting, flushing, redness, irregular heart beat (palpitations), trouble breathing, wheezing, dizziness or light-headedness, swelling of the lips, skin rash, headache, or itching.
  • The most common side effects of SYLVANT include rash, itching, upper respiratory tract infection, swelling, weight gain, and increased blood level of uric acid.

These are not all the possible side effects of SYLVANT. Call your HCP for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Call 1-800-FDA-1088 or visit www.fda.gov/medwatch.

SYLVANT® (siltuximab) for injection, for intravenous use, is available as 100 mg or 400 mg of lyophilized powder in a single-dose vial.

Please see full Prescribing Information, including Patient Information.

What is SYLVANT?

SYLVANT® (siltuximab) is a prescription medicine used to treat people with multicentric Castleman’s disease (MCD) who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection. It is not known if SYLVANT is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Who should not receive SYLVANT?

Do not receive SYLVANT if you have had a severe allergic reaction to siltuximab or any of the ingredients in SYLVANT. See the Patient Information leaflet for SYLVANT for a complete list of ingredients.