Understanding idiopathic multicentric
Castleman disease (iMCD)
Recognizing the Symptoms of iMCD
Here are a few iMCD symptoms that will help you better understand the disease and what to look for:
Swollen Lymph Nodes
Swollen lymph nodes are one of your body’s natural reactions to illness or infection
Fatigue
Fatigue is defined as an overall feeling of tiredness or having low energy
Night Sweats
Excessive sweating while you sleep
Fever
An increase in normal body temperature, a key sign that your immune system has been activated
Anemia
A condition in which a person has a low red blood cell count and might feel tired
Malaise
Malaise is a general feeling of discomfort, illness, or lack of well-being
Unexplained Weight Loss
Unexpected change in weight can be a sign of an underlying medical condition
The symptoms that led up to my iMCD diagnosis included visibly swollen lymph nodes, fatigue, night sweats, headaches, and nausea.
Do these symptoms sound familiar?
Getting to an iMCD diagnosis may be difficult—symptoms of iMCD can range from mild to severe and look like other disorders.
IL-6, interleukin-6; R.A.R.E., Recordati Access, Resources, and Engagement.
What is SYLVANT?
SYLVANT® (siltuximab) is a prescription medicine used to treat people with multicentric Castleman’s disease (MCD) who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection. It is not known if SYLVANT is safe and effective in children.
IMPORTANT SAFETY INFORMATION
Who should not receive SYLVANT?
Do not receive SYLVANT if you have had a severe allergic reaction to siltuximab or any of the ingredients in SYLVANT. See the Patient Information leaflet for SYLVANT for a complete list of ingredients.
Before starting SYLVANT, tell your healthcare provider (HCP) about all of your medical conditions, including if you:
- have an infection. You should not receive SYLVANT if you have a severe infection.
- have had a recent vaccination or are scheduled to receive any vaccinations. You should not receive a live vaccine during your treatment with SYLVANT.
- have or have had any stomach or bowel (intestine) problems, such as diverticulitis or ulcers. Tell your healthcare provider if you have pain in your stomach area.
- are pregnant or plan to become pregnant. It is not known if SYLVANT will harm your unborn baby. You should not become pregnant while receiving treatment with SYLVANT. Females who are able to become pregnant should use effective birth control during treatment with SYLVANT and for 3 months after stopping treatment.
- are breastfeeding or plan to breastfeed. It is not known if SYLVANT passes into your breast milk. You and your healthcare provider should decide if you will take SYLVANT or breastfeed. You should not do both.Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of SYLVANT?
SYLVANT may cause serious side effects, including:
- Infections. SYLVANT may lower your ability to fight infections. Tell your healthcare provider right away if you have any signs or symptoms of an infection during treatment with SYLVANT.
- Infusion and allergic reactions. If you have an infusion or allergic reaction while receiving SYLVANT, your healthcare provider will stop your infusion and treat your reaction. If you have a severe infusion or allergic reaction, your healthcare provider may stop your treatment completely. Tell your healthcare provider or get medical help right away if you have any of these symptoms during or after your infusion of SYLVANT: back pain, chest pain or tightness, nausea and vomiting, flushing, redness, irregular heart beat (palpitations), trouble breathing, wheezing, dizziness or light-headedness, swelling of the lips, skin rash, headache, or itching.
- The most common side effects of SYLVANT include rash, itching, upper respiratory tract infection, swelling, weight gain, and increased blood level of uric acid.
These are not all the possible side effects of SYLVANT. Call your HCP for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Call 1-800-FDA-1088 or visit www.fda.gov/medwatch.
SYLVANT® (siltuximab) for injection, for intravenous use, is available as 100 mg or 400 mg of lyophilized powder in a single-dose vial.
Please see full Prescribing Information, including Patient Information.
