Treatment with SYLVANT®


SYLVANT® (siltuximab) blocks the action of interleukin-6 (IL-6)

SYLVANT® works by blocking the action of an important protein called interleukin-6 (IL-6), a substance produced in the lymph nodes. SYLVANT® is a monoclonal antibody that prevents IL-6 from binding to IL-6 receptors.

How SYLVANT® is administered


How will I receive SYLVANT® (siltuximab)?

You will receive SYLVANT® at a hospital or clinic every 3 weeks. A nurse or doctor will give you the medicine through an intravenous infusion . It takes about an hour to complete the SYLVANT® infusion, and you will be monitored for any possible side effects.


SYLVANT® (siltuximab) may cause serious side effects, including:


SYLVANT® may lower your ability to fight infections. Tell your healthcare provider right away if you have any signs or symptoms of an infection during treatment with SYLVANT®.

Infusion and allergic reactions

If you have an infusion or allergic reaction while receiving SYLVANT®, your healthcare provider will stop your infusion and treat your reaction. If you have a severe infusion or allergic reaction, your healthcare provider may stop your treatment completely. Tell your healthcare provider or get medical help right away if you have any of these symptoms during or after your infusion of SYLVANT®: trouble breathing, chest tightness, wheezing, dizziness or lightheadedness, swelling of the lips, or skin rash.

The most common SYLVANT® side effects include:

  • Rash
  • Itching
  • Upper respiratory infection
  • Weight gain
  • Increased blood level of uric acid

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SYLVANT®. Call your doctor for medical advice about side effects.

General information about safe and effective use of SYLVANT®

General information about the safe and effective use of SYLVANT®

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your healthcare provider or pharmacist for information about SYLVANT® that is written for health professionals.

Report any signs of new or worsening medical conditions to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit, or
call 1-800-FDA-1088 (1-800-332-1088).


Even if you are not experiencing symptoms and are feeling better, it is important to continue to receive treatment with SYLVANT® (siltuximab) for as long as your doctor recommends.